Biomimetic Self-assembled Nanomatrix for Bone Tissue Regeneration
نویسندگان
چکیده
...........................................................................................................................iii ACKNOWLEDGMENTS ....................................................................................................... v LIST OF FIGURES ................................................................................................................ ix LIST OF ABBREVIATIONS ................................................................................................. x INTRODUCTION ................................................................................................................... 1 Bone Structure .................................................................................................................. 4 Clinical Significance ........................................................................................................ 6 Previous Strategies for Bone Tissue Regeneration ........................................................ 7 Creating Biomimetic Self-Assembled Peptide Amphiphile Nanomatrix Scaffold ... 10 Peptide Amphiphiles ...................................................................................................... 13 Cell Adhesive Ligands Sequences Incorporated into Peptide Amphiphiles .............. 16 Hydroxyapatite and Tetracalcium Phosphate ............................................................... 18 Mesenchymal Stem Cells .............................................................................................. 19 Previous Studies to Differentiate Mesenchymal Stem Cells into Osteoblasts ........... 22 Osteoblast Differentiation Markers .............................................................................. 24 SPECIFIC AIMS ................................................................................................................... 25 Scope of Study ............................................................................................................... 25 Specific Aim 1 ................................................................................................................ 25
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تاریخ انتشار 2008